Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training
B Egan, AP Sharples - Physiological Reviews, 2023 - journals.physiology.org
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …
exercise training are a potent stimulus for physiological adaptation in many organs …
Metformin and insulin resistance: a review of the underlying mechanisms behind changes in GLUT4-mediated glucose transport
R Herman, NA Kravos, M Jensterle, A Janež… - International journal of …, 2022 - mdpi.com
Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-
resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and …
resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and …
Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function
A key metabolic activity of the gut microbiota is the fermentation of non-digestible
carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end …
carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end …
[HTML][HTML] Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk
Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …
Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
SL McGee, M Hargreaves - Nature Reviews Endocrinology, 2020 - nature.com
Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …
diseases of modern society. It is well appreciated that regular exercise improves metabolism …
[HTML][HTML] AMPK in skeletal muscle function and metabolism
R Kjøbsted, JR Hingst, J Fentz, M Foretz… - The FASEB …, 2018 - ncbi.nlm.nih.gov
Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …
AMPK: an energy-sensing pathway with multiple inputs and outputs
AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …
Insulin signal transduction perturbations in insulin resistance
Type 2 diabetes mellitus is a widespread medical condition, characterized by high blood
glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance …
glucose and inadequate insulin action, which leads to insulin resistance. Insulin resistance …
Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …
Lysine acetylation goes global: from epigenetics to metabolism and therapeutics
Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …