Human serum albumin (HSA) is an abundant transport protein found in plasma that binds a
wide variety of drugs in two primary binding sites (I and II) and can have a significant impact …

The anticoagulant drug warfarin, normally administered as the racemate, can exist in
solution in potentially as many as 40 topologically distinct tautomeric forms. Only 11 of these …

The various stages involved in the transport, pharmacological action and elimination of
warfarin involve the specific binding of warfarin to a chiral macromolecular complex …

We have developed a general, two-step protocol for the synthesis of chiral non-racemic
coumarin anticoagulants (eg warfarin, coumachlor and acenocoumarol). This approach …

4-Hydroxycoumarins such as warfarin 1 have been the mainstay of oral anticoagulation
therapy for over 20 years. Yet little detail is known about the molecular interactions between …

Possible reasons for the observed differences in metabolic behavior and drug interaction
liability between the structurally similar oral anticoagulants warfarin and phenprocoumon …

Warfarin, an important anticoagulant drug, can exist in solution in 40 distinct tautomeric
forms through both prototropic tautomerism and ring–chain tautomerism. We have …

Optical spectroscopy was used to examine the binding of ochratoxin A (OTA) and warfarin
(WAR) to human serum albumin (HSA). Both molecules in the deprotonated form showed …

A compound exhibits (prototropic) tautomerism if it can be represented by two or more
structures that are related by a formal intramolecular movement of a hydrogen atom from …

The photophysical behavior of the isomers of the anticoagulant drug warfarin in various
solvents and solvent mixtures was investigated using absorption, 1H NMR, and steady-state …