Patients with inflammatory bowel disease (IBD) are at increased risk of developing
colorectal cancer (CRC), despite decreases in CRC incidence in recent years. Chronic …

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Oral antioxidant nanozymes bring great promise for inflammatory bowel disease (IBD)
treatment. To efficiently eliminate reactive oxygen species (ROS), various metal‐based …

With ageing, normal human tissues experience an expansion of somatic clones that carry
cancer mutations,,,,,–. However, whether such clonal expansion exists in the non-neoplastic …

Background & Aims Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory
disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC …

Chronic inflammation is accompanied by recurring cycles of tissue destruction and repair
and is associated with an increased risk of cancer,–. However, how such cycles affect the …

Background Immune checkpoint inhibitors (ICIs), including anti-PD-1 therapy, have limited
efficacy in patients with microsatellite stable (MSS) colorectal cancer (CRC). Interleukin 17A …

Increased risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients has
been attributed to long-standing chronic inflammation, with the contribution of genetic …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with
increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts …