Highlights•C. difficile spore germination is regulated by two pseudoproteases.•The CspC
germinant receptor and pseudoprotease regulates bile acid and co-germinant …

Clostridioides difficile (CD) is a Gram-positive, anaerobic bacterium that infects mainly
hospitalized and elderly people who have been treated with long-term antibiotic therapy …

Clostridioides difficile is a Gram-positive, spore-forming obligate anaerobe and a major
threat to the healthcare system world-wide. Because of its strict anaerobic requirements, the …

Clostridium difficile (C. difficile) is an exclusively anaerobic, spore-forming, and Gram-
positive pathogen that is the most common cause of nosocomial diarrhea and is becoming …

Clostridioides difficile (C. difficile) is a Gram-positive, spore-forming, toxin-producing,
obligate anaerobic bacterium. C. difficile infection (CDI) is the leading cause of healthcare …

This narrative review summarizes literature on C. difficile and C. difficile infections (CDI) that
emerged from Latin America (LA) between 1984 and 2021. The revised information includes …

Clostridioides difficile spores are the infective form for this endospore-forming organism. The
vegetative cells are intolerant to oxygen and poor competitors with a healthy gut microbiota …

Clostridioides difficile is Gram-positive spore-former bacterium and the leading cause of
nosocomial antibiotic-associated diarrhea. During disease, C. difficile forms metabolically …

Clostridioides difficile spores are essential for initiation, recurrence and transmission of the
disease. The spore surface layers are composed of an outermost exosporium layer that …

Uma das dificuldades para tratar a infecção por Clostridioides difficile (ICD) é que essa
bactéria, possui diversos fatores de virulência, dentre estes a formação de biofilmes …