The discovery in the early 1980s that protein kinase C is 'the receptor'for the tumor-
promoting phorbol esters catapulted this enzyme to the forefront of research in signal …

▪ Abstract Research in the past decade has revealed that many cytosolic proteins are
recruited to different cellular membranes to form protein-protein and lipid-protein interactions …

In mammalian cells, phospholipids and cholesterol are assembled into bilayer membranes
forming the plasma membrane, nuclear envelope, mitochondria, endoplasmic reticulum …

Phosphatidylserine (PS) is a quantitatively minor membrane phospholipid that is
synthesized by prokaryotic and eukaryotic cells. In this review we focus on genes and …

Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are two aminophospholipids
whose metabolism is inter-related. Both phospholipids are components of mammalian cell …

Diacylglycerol (DAG) has unique functions as a basic component of membranes, an
intermediate in lipid metabolism and a key element in lipid-mediated signaling. In …

Phosphatidic acid and phosphatidylserine are negatively charged abundant phospholipids
with well-recognized structural roles in cellular membranes. They are also signaling lipids …

C2 domains are membrane-binding modules that share a common overall fold: a single
compact Greek-key motif organized as an eight-stranded anti-parallel β-sandwich consisting …

C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes,
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …

Abstract p47 phox is a key cytosolic subunit required for activation of phagocyte NADPH
oxidase. The X‐ray structure of the p47 phox PX domain revealed two distinct basic pockets …