Advanced liposome and polymersome-based drug delivery systems: Considerations for physicochemical properties, targeting strategies and stimuli-sensitive …

S Kansız, YM Elçin - Advances in Colloid and Interface Science, 2023 - Elsevier
Liposomes and polymersomes are colloidal vesicles that are self-assembled from lipids and
amphiphilic polymers, respectively. Because of their ability to encapsulate both hydrophilic …

Innovative nanomaterials for cancer diagnosis, imaging, and therapy: Drug delivery applications

M Pourmadadi, MM Eshaghi, S Ostovar… - Journal of Drug Delivery …, 2023 - Elsevier
The emergence of nanomedicine drugs as a result of the fast advancement of
nanotechnology offers enormous potential for improving cancer treatment strategies. The …

Polymer micropatches as natural killer cell engagers for tumor therapy

S Prakash, N Kumbhojkar, A Lu, N Kapate, VC Suja… - ACS …, 2023 - ACS Publications
Natural killer (NK) cell therapies have emerged as a potential therapeutic approach to
various cancers. Their efficacy, however, is limited by their low persistence and anergy …

Shape matters: Biodegradable anisotropic nanoparticle artificial antigen presenting cells for cancer immunotherapy

E Ben-Akiva, JW Hickey, RA Meyer, A Isser… - Acta biomaterialia, 2023 - Elsevier
Artificial antigen presenting cells are biomimetic particles that recapitulate the signals
presented by natural antigen presenting cells in order to stimulate T cells in an antigen …

Particle-Based Artificial Antigen-Presenting Cell Systems for T Cell Activation in Adoptive T Cell Therapy

F Hou, Z Guo, MT Ho, Y Hui, CX Zhao - ACS nano, 2024 - ACS Publications
T cell-based adoptive cell therapy (ACT) has emerged as a promising treatment for various
diseases, particularly cancers. Unlike other immunotherapy modalities, ACT involves directly …

Artificial cells for in vivo biomedical applications through red blood cell biomimicry

J Waeterschoot, W Gosselé, Š Lemež… - Nature …, 2024 - nature.com
Recent research in artificial cell production holds promise for the development of delivery
agents with therapeutic effects akin to real cells. To succeed in these applications, these …

Polymersomes with splenic avidity target red pulp myeloid cells for cancer immunotherapy

AC Wauters, JF Scheerstra, MMT van Leent… - Nature …, 2024 - nature.com
Regulating innate immunity is an emerging approach to improve cancer immunotherapy.
Such regulation requires engaging myeloid cells by delivering immunomodulatory …

Targeting intracellular and extracellular receptors with nano-to-macroscale biomaterials to activate immune cells

B Wang, H Cui, F Kiessling, T Lammers… - Journal of Controlled …, 2023 - Elsevier
Activation of immune cells is an essential process in innate and adaptive immunity. A high
number of immune cell activation pathways have been discovered, which are stimulated via …

Biomaterials to enhance adoptive cell therapy

N Eckman, A Nejatfard, R Cavet… - Nature Reviews …, 2024 - nature.com
Adoptive cell therapy (ACT) harnesses the capabilities of immune cells to fight complex
diseases such as cancer. Treatment with adoptive transfer of engineered cells has led to …

Spiky Gold Nanoparticles, a Nanoscale Approach to Enhanced Ex Vivo T-Cell Activation

F Esmaeili, YL Wu, Z Wang, A Abdrabou, VB Juska… - ACS …, 2024 - ACS Publications
While existing synthetic technologies for ex vivo T-cell activation face challenges like
suboptimal expansion rates and low effectiveness, artificial antigen-presenting cells …