The process of cell division plays a vital role in cancer progression. Cell proliferation and
error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes …

Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is
caused by chromosome segregation errors during cell divisions. Evidence is mounting that …

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of
which cannot be easily classified into simple (eg, deletion) or complex (eg, chromothripsis) …

Background & Aims Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory
disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC …

APOBEC mutagenesis, a major driver of cancer evolution, is known for targeting TpC sites in
DNA. Recently, we showed that APOBEC3A (A3A) targets DNA hairpin loops. Here, we …

CRISPR-Cas9 genome editing has promising therapeutic potential for genetic diseases and
cancers, but safety could be a concern. Here we use whole genomic analysis by 10x linked …

Complex genomic rearrangements (CGRs) are common in cancer and are known to form via
two aberrant cellular structures—micronuclei and chromatin bridges. However, which of …

Background Neoantigens are critical for anti-tumor immunity and have been long-
envisioned as promising therapeutic targets. However, current neoantigen analyses mostly …

Renal medullary carcinoma (RMC) is a highly lethal malignancy that mainly afflicts young
individuals of African descent and is resistant to all targeted agents used to treat other renal …

Oncogene activation during tumorigenesis generates DNA replication stress, a known driver
of genome rearrangements. In response to replication stress, certain loci, such as common …