Therapeutic peptides: current applications and future directions

L Wang, N Wang, W Zhang, X Cheng, Z Yan… - Signal transduction and …, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

Peptides for vaccine development

IW Hamley - ACS Applied Bio Materials, 2022 - ACS Publications
This review discusses peptide epitopes used as antigens in the development of vaccines in
clinical trials as well as future vaccine candidates. It covers peptides used in potential …

Predicting epitopes for vaccine development using bioinformatics tools

V Yurina, OR Adianingsih - Therapeutic advances in …, 2022 - journals.sagepub.com
Epitope-based DNA vaccine development is one application of bioinformatics or in silico
studies, that is, computational methods, including mathematical, chemical, and biological …

Peptides: Prospects for Use in the Treatment of COVID-19

V Khavinson, N Linkova, A Dyatlova, B Kuznik… - Molecules, 2020 - mdpi.com
There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease
inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and …

Antimicrobial and amyloidogenic activity of peptides. Can antimicrobial peptides be used against SARS-CoV-2?

SR Kurpe, SY Grishin, AK Surin, AV Panfilov… - International Journal of …, 2020 - mdpi.com
At present, much attention is paid to the use of antimicrobial peptides (AMPs) of natural and
artificial origin to combat pathogens. AMPs have several points that determine their …

A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron

I Palatnik-de-Sousa, ZS Wallace, SC Cavalcante… - Scientific reports, 2022 - nature.com
COVID-19 caused, as of September, 1rst, 2022, 599,825,400 confirmed cases, including
6,469,458 deaths. Currently used vaccines reduced severity and mortality but not virus …

CD8+ T-cell immune escape by SARS-CoV-2 variants of concern

AJ Kombe Kombe, FAN Biteghe… - Frontiers in …, 2022 - frontiersin.org
Despite the efficacy of antiviral drug repositioning, convalescent plasma (CP), and the
currently available vaccines against severe acute respiratory syndrome coronavirus 2 …

An in-depth in silico and immunoinformatics approach for designing a potential multi-epitope construct for the effective development of vaccine to combat against …

A Al Saba, M Adiba, P Saha, MI Hosen… - Computers in biology …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the latest of the several
viral pathogens that have acted as a threat to human health around the world. Thus, to …

IntegralVac: a machine learning-based comprehensive multivalent epitope vaccine design method

S Suri, S Dakshanamurthy - Vaccines, 2022 - mdpi.com
In the growing field of vaccine design for COVID and cancer research, it is essential to
predict accurate peptide binding affinity and immunogenicity. We developed a …

Immunoinformatics study: multi-epitope based vaccine design from SARS-CoV-2 spike glycoprotein

R Umitaibatin, AH Harisna, MM Jauhar, PH Syaifie… - Vaccines, 2023 - mdpi.com
The coronavirus disease 2019 outbreak has become a huge challenge in the human sector
for the past two years. The coronavirus is capable of mutating at a higher rate than other …