[HTML][HTML] Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease

K Pafili, S Kahl, L Mastrototaro, K Strassburger… - Journal of …, 2022 - Elsevier
Background & Aims Adipose tissue dysfunction is involved in the development of insulin
resistance and is responsible for excessive lipid delivery to other organs such as the liver …

High-throughput proteomics uncovers exercise training and type 2 diabetes–induced changes in human white adipose tissue

JK Larsen, R Kruse, N Sahebekhtiari… - Science …, 2023 - science.org
White adipose tissue (WAT) is important for metabolic homeostasis. We established the
differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and …

The Role Played by Mitochondria in Polycystic Ovary Syndrome

C Sun, S Zhao, Z Pan, J Li, Y Wang… - DNA and Cell Biology, 2024 - liebertpub.com
Polycystic ovary syndrome (PCOS) refers to an endocrine disorder syndrome that are
correlated with multiple organs and systems. PCOS has an effect on women at all stages of …

Dissecting human adipose tissue heterogeneity using single‐cell omics technologies

G Di Rocco, A Trivisonno, G Trivisonno… - Stem Cell Research & …, 2024 - Springer
Single-cell omics technologies that profile genes (genomic and epigenomic) and determine
the abundance of mRNA (transcriptomic), protein (proteomic and secretomic), lipids …

Concentration of polycyclic aromatic hydrocarbons (PAHs) in human serum and adipose tissues and stimulatory effect of naphthalene in adipogenesis in 3T3-L1 cells

E Mlyczyńska, A Bongrani, C Rame, M Węgiel… - International Journal of …, 2023 - mdpi.com
Polycyclic aromatic hydrocarbons (PAHs) are one of the most prevalent classes of
environmental pollutants. Some evidence shows that PAHs could be involved in human …

Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers

P Hruska, J Kucera, D Kuruczova… - American Journal …, 2023 - journals.physiology.org
In this study, we aimed to comprehensively characterize the proteomic landscapes of
subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in patients with …

Deep proteome profiling of white adipose tissue reveals marked conservation and distinct features between different anatomical depots

S Madsen, ME Nelson, V Deshpande… - Molecular & Cellular …, 2023 - ASBMB
White adipose tissue is deposited mainly as subcutaneous adipose tissue (SAT), often
associated with metabolic protection, and abdominal/visceral adipose tissue, which …

Clinically relevant plasma proteome for adiposity depots: evidence from systematic mendelian randomization and colocalization analyses

M Cao, B Cui - Cardiovascular Diabetology, 2024 - Springer
Background The accumulation of visceral and ectopic fat comprise a major cause of
cardiometabolic diseases. However, novel drug targets for reducing unnecessary visceral …

Systems biology approaches to inform precision nutrition

KAJ Mitchelson, MBN Chathail… - Proceedings of the …, 2023 - cambridge.org
The precision nutrition paradigm is based on the premise that substantial variation exists
between human subjects in terms of diet-related disease risk and response to dietary …

Transcript profile of CLSTN3B gene in human white adipose tissue is associated with obesity and mitochondrial gene program

N Bai, X Lu, Y Wang, X Li, R Zhang, H Yu, C Hu… - Life …, 2023 - academic.oup.com
Obesity is a major health issue with global prevalence and increases the risk of many
metabolic diseases. Of particular concern is the increasing incidence of type 2 diabetes, the …