Current strategies for inhibition of chikungunya infection

BB Subudhi, S Chattopadhyay, P Mishra, A Kumar - Viruses, 2018 - mdpi.com
Increasing incidences of Chikungunya virus (CHIKV) infection and co-infections with
Dengue/Zika virus have highlighted the urgency for CHIKV management. Failure in …

Antivirals against the Chikungunya virus

V Battisti, E Urban, T Langer - Viruses, 2021 - mdpi.com
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in
recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection …

Understanding the binding affinity of noscapines with protease of SARS-CoV-2 for COVID-19 using MD simulations at different temperatures

D Kumar, K Kumari, A Jayaraj, V Kumar… - Journal of …, 2021 - Taylor & Francis
The current outbreak of a novel coronavirus, named as SARS-CoV-2 causing COVID-19
occurred in 2019, is in dire need of finding potential therapeutic agents. Recently, ongoing …

Growth in chikungunya virus-related research in ASEAN and South Asian countries from 1967 to 2022 following disease emergence: a bibliometric and graphical …

F Sofyantoro, A Frediansyah, DS Priyono… - Globalization and …, 2023 - Springer
Abstract Background ASEAN (Association of Southeast Asian Nations) is composed of ten
Southeast Asian countries bound by socio-cultural ties that promote regional peace and …

Current status of chikungunya in India

… Consortia (TRC) for Chikungunya Virus in … - Frontiers in …, 2021 - frontiersin.org
Chikungunya fever (CHIKF) is an arbovirus disease caused by chikungunya virus (CHIKV),
an alphavirus of Togaviridae family. Transmission follows a human-mosquito-human cycle …

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue

K Rausalu, A Utt, T Quirin, FS Varghese, E Žusinaite… - Scientific reports, 2016 - nature.com
Chikungunya virus (CHIKV), genus Alphavirus, family Togaviridae, has a positive-stand
RNA genome approximately 12 kb in length. In infected cells, the genome is translated into …

In silico study on anti-Chikungunya virus activity of hesperetin

A Oo, P Hassandarvish, SP Chin, VS Lee, SA Bakar… - PeerJ, 2016 - peerj.com
Background The re-emerging, Aedes spp. transmitted Chikungunya virus (CHIKV) has
recently caused large outbreaks in a wide geographical distribution of the world including …

In silico studies revealed interaction mechanisms of benzylidene–acrylohydrazide derivatives and nsP2 CHIKV

LS Muniz, SS da Rocha Pita - New Journal of Chemistry, 2022 - pubs.rsc.org
The Chikungunya virus (CHIKV, Togaviridae family, Alphavirus genus) represents an
emerging public health problem worldwide because it causes high morbidity and mortality …

A review on structural genomics approach applied for drug discovery against three vector-borne viral diseases: Dengue, Chikungunya and Zika

S Sundar, S Piramanayagam, J Natarajan - Virus Genes, 2022 - Springer
Structural genomics involves the advent of three-dimensional structures of the genome
encoded proteins through various techniques available. Numerous structural genomics …

Exploring the effect of temperature on inhibition of non-structural protease 3 of Chikungunya virus using molecular dynamics simulations and thermodynamics …

D Kumar, MK Meena, K Kumari, RV Kumar… - Journal of Molecular …, 2021 - Elsevier
Chikungunya viral infections are creating problems in humans, therefore, there is a need to
find promising drugs to cure the patients. As of today, there is no promising and efficient drug …