The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced
countries accompanied by the high prevalence of risk factors. In terms of pathogenesis, the …

Biochemical crosstalk between two or more histone modifications is often observed in
epigenetic enzyme regulation, but its functional significance in cells has been difficult to …

Lysine-specific demethylase 1 (LSD1) is a promising therapeutic target for cancer therapy.
So far, over 80 crystal structures of LSD1 in different complex states have been deposited in …

The chromatin structure is dynamically regulated by many different modulators that post-
translationally modify histones, replace canonical histones with histone variants, and unwind …

Background Lysine-specific demethylase 1 (LSD1) is an essential epigenetic regulator of
hematopoietic differentiation, which can specifically mono-methylate H3K4 (H3K4me1) and …

Transcriptional coregulators and transcription factors (TFs) contain intrinsically disordered
regions (IDRs) that are critical for their association and function in gene regulation. More …

LSD1 plays a crucial role in mammalian biology, regulated through interactions with
coregulators and post-translational modifications. Here we show that the kinase NEK6 …

Lysine specific demethylase-1 (LSD1) serves as a regulator of transcription and represents
a promising epigenetic target for anticancer treatment. LSD1 inhibitors are in clinical trials for …

The N-terminal region of the human lysine-specific demethylase 1 (LSD1) has no predicted
structural elements, contains a nuclear localization signal (NLS), undergoes multiple …

Protein methylation is crucial in epigenetics, and targeting the involved methyltransferases
shows great potential for therapeutic intervention with several inhibitors in clinical trials for …