Mining and unearthing hidden biosynthetic potential
K Scherlach, C Hertweck - Nature Communications, 2021 - nature.com
Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …
On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi
BT Pfannenstiel, NP Keller - Biotechnology advances, 2019 - Elsevier
Fungi produce an abundance of bioactive secondary metabolites which can be utilized as
antibiotics and pharmaceutical drugs. The genes encoding secondary metabolites are …
antibiotics and pharmaceutical drugs. The genes encoding secondary metabolites are …
Streptomyces polyketides mediate bacteria–fungi interactions across soil environments
MKC Krespach, MC Stroe, T Netzker, M Rosin… - Nature …, 2023 - nature.com
Although the interaction between prokaryotic and eukaryotic microorganisms is crucial for
the functioning of ecosystems, information about the processes driving microbial interactions …
the functioning of ecosystems, information about the processes driving microbial interactions …
Filamentous fungi for the production of enzymes, chemicals and materials
HAB Wösten - Current opinion in biotechnology, 2019 - Elsevier
Highlights•Fungi can be used as a cell factory and for production of mycelium
materials.•Monofungal and mixed fungal cultures produce different profiles of secreted …
materials.•Monofungal and mixed fungal cultures produce different profiles of secreted …
Post-translational regulation of autophagy is involved in intra-microbiome suppression of fungal pathogens
Background Microbiome interactions are important determinants for ecosystem functioning,
stability, and health. In previous studies, it was often observed that bacteria suppress …
stability, and health. In previous studies, it was often observed that bacteria suppress …
Chemical mediators at the bacterial-fungal interface
K Scherlach, C Hertweck - Annual Review of Microbiology, 2020 - annualreviews.org
Interactions among microbes are key drivers of evolutionary progress and constantly shape
ecological niches. Microorganisms rely on chemical communication to interact with each …
ecological niches. Microorganisms rely on chemical communication to interact with each …
Unlocking the trove of metabolic treasures: activating silent biosynthetic gene clusters in bacteria and fungi
X Zhang, MA Elliot - Current opinion in microbiology, 2019 - Elsevier
Highlights•Silent BGC expression can be promoted by creative co-culture and elicitor
exposure.•Novel regulators are enabling new approaches to stimulating BGC …
exposure.•Novel regulators are enabling new approaches to stimulating BGC …
In the fungus where it happens: history and future propelling Aspergillus nidulans as the archetype of natural products research
In 1990 the first fungal secondary metabolite biosynthetic gene was cloned in Aspergillus
nidulans. Thirty years later,> 30 biosynthetic gene clusters (BGCs) have been linked to …
nidulans. Thirty years later,> 30 biosynthetic gene clusters (BGCs) have been linked to …
CRISPR-mediated activation of biosynthetic gene clusters for bioactive molecule discovery in filamentous fungi
Accessing the full biosynthetic potential encoded in the genomes of fungi is limited by the
low expression of most biosynthetic gene clusters (BGCs) under common laboratory culture …
low expression of most biosynthetic gene clusters (BGCs) under common laboratory culture …
Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture
Actinomycetes are a rich source of bioactive natural products important for novel drug leads.
Recent genome mining approaches have revealed an enormous number of secondary …
Recent genome mining approaches have revealed an enormous number of secondary …