Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

Evidence suggests that adverse experiences in childhood are associated with psychosis. To
examine the association between childhood adversity and trauma (sexual abuse, physical …

Context A substantial proportion of people at clinical high risk of psychosis will develop a
psychotic disorder over time. However, the risk of transition to psychosis varies between …

The aim of this guidance paper of the European Psychiatric Association is to provide
evidence-based recommendations on the early detection of a clinical high risk (CHR) for …

How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …

Although dementia praecox or schizophrenia has been considered a unique disease entity
for the past century, its definitions and boundaries have continued to vary over this period. At …

An accurate detection of individuals at clinical high risk (CHR) for psychosis is a prerequisite
for effective preventive interventions. Several psychometric interviews are available, but their …

Objective: A major focus of early intervention research is determining the risk of conversion
to psychosis and developing optimal algorithms of prediction. Although reported rates of …

BackgroundThe nosology of the psychosis high-risk state is controversial. Traditionally
conceived as an 'at risk'state for the development of psychotic disorders, it is also …

Context Indicated prevention is currently regarded as the most promising strategy to
attenuate, delay, or even avert psychosis. Existing criteria need improvement in terms of …