Significance: Oxygen is indispensable for aerobic life, but its utilization exposes cells and
tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen …

Alveolar hypoxia is the most prominent feature of high altitude environment with well-known
consequences for the cardio-pulmonary system, including development of pulmonary …

Purpose Main purposes of pre-acclimatization by hypoxia conditioning (HC) are the
prevention of high-altitude illnesses and maintenance of aerobic exercise performance …

The (patho-) physiological responses to hypoxia are highly heterogeneous between
individuals. In this review, we focused on the roles of sex differences, which emerge as …

BACKGROUND. Iron bioavailability has been identified as a factor that influences cellular
hypoxia sensing, putatively via an action on the hypoxia-inducible factor (HIF) pathway. We …

Over the last 100 years, high‐altitude researchers have amassed a comprehensive
understanding of the global cardiac responses to acute, prolonged and lifelong hypoxia …

We have recently reported that hypobaric hypoxia (HH) reduces plasma volume (PV) in men
by decreasing total circulating plasma protein (TCPP). Here, we investigated whether this …

This pre-eminent work has developed over six editions in response to man's attempts to
climb higher and higher unaided, and to spend more time at altitude for both work and …

The human pulmonary vasculature vasoconstricts in response to a reduction in alveolar
oxygen tension, a phenomenon termed hypoxic pulmonary vasoconstriction (HPV). This …

Hypoxia can have significant impacts on cardiovascular physiology, but the effects of chronic
exposure to moderate hypoxia and how they differ between sexes remain poorly …