To resolve the growing problem of drug resistance in the treatment of bacterial and fungal
pathogens, specific cellular targets and pathways can be used as targets for new …

Multiple drug resistance is the main obstacle in the treatment of bacterial diseases.
Resistance against antibiotics demands the exploration of new antimicrobial drug targets. A …

Genetic engineering provides various avenues for CO 2 transformation into biological matter
or bio-substances, aiding in mitigating the unsustainable utilization of organic raw materials …

Calprotectin (CP) inhibits bacterial viability through extracellular chelation of transition
metals. However, how CP influences general metabolism remains largely unexplored. We …

Cyanobacteria are attractive hosts for photosynthetic terpenoid production, using CO2 as the
sole carbon source. Although the methylerythritol phosphate (MEP) pathway is superior to …

Background Riboflavin is the precursor of several cofactors essential for normal physical
and cognitive development, but only plants and some microorganisms can produce it …

Active flavins derived from riboflavin (vitamin B2) are essential for life. Bacteria
biosynthesize riboflavin or scavenge it through uptake systems, and both mechanisms may …

Abstract Background The soil bacterium Pseudomonas putida is a promising platform for the
production of industrially valuable natural compounds. In the case of isoprenoids, the …

RibB (3, 4-dihydroxy-2-butanone 4-phosphate synthase) is a magnesium-dependent
enzyme that excises the C4 of d-ribulose-5-phosphate (d-Ru5P) as formate. RibB generates …

Riboflavin (vitamin B2) is the precursor of the flavin coenzymes, FAD and FMN, which play a
central role in cellular redox metabolism. While humans must obtain riboflavin from dietary …