An update on solid-state form, crystal modification and transition issues related to tablet manufacturing
S Zhou, T Yang, C Qian, F Wu, Y Hong, X Lin - Journal of Drug Delivery …, 2024 - Elsevier
Improving the tableting-related properties (flowability, compressibility, compactibility, etc.) of
pharmaceutical materials, especially active pharmaceutical ingredients (APIs), is critical for …
pharmaceutical materials, especially active pharmaceutical ingredients (APIs), is critical for …
A double-layered gastric floating tablet for zero-order controlled release of dihydromyricetin: Design, development, and in vitro/in vivo evaluation
R Zhang, H Shi, S Li, H Zhang, D Zhang, A Wu… - International Journal of …, 2023 - Elsevier
Dihydromyricetin (DHM) is an important natural flavonoid. However, most of DHM
preparations have shown shortcomings such as low drug loading, poor drug stability, and/or …
preparations have shown shortcomings such as low drug loading, poor drug stability, and/or …
Elaborating the crystal transformation referenced microhydrodynamic model and fracture mechanism combined molecular modelling of irbesartan nanosuspensions …
T Meng, Y Li, S Ma, Q Zhang, F Qiao, Y Hou… - International Journal of …, 2023 - Elsevier
In recent years, polymorphic transformation involved in media milling has become a key
factor in inducing the instability of nanosuspensions (NSs). The variation trend of …
factor in inducing the instability of nanosuspensions (NSs). The variation trend of …
Packing and Conformational Polymorphism in 1,2-Bis(aminocarbonyl(1-tert-butyl-1H-pyrazol-(3)5-yl))ethanes: Illuminating Examples of Highly Flexible Molecules
GC Zimmer, AB Pagliari, VB Solner… - Crystal Growth & …, 2021 - ACS Publications
Insights into the occurrence of packing and conformational polymorphs and
anhydrous/hydrate forms of 1, 2-bis (aminocarbonyl (1-tert-butyl-1 H-pyrazol-[3] 5-yl)) …
anhydrous/hydrate forms of 1, 2-bis (aminocarbonyl (1-tert-butyl-1 H-pyrazol-[3] 5-yl)) …
Exploring the influence factors and improvement strategies of drug polymorphic transformation combined kinetic and thermodynamic perspectives during the formation …
T Meng, F Qiao, S Ma, T Gao, L Li, Y Hou… - Drug Development and …, 2021 - Taylor & Francis
Nanosuspensions can effectively increase saturation solubility and improve the
bioavailability of poorly water-soluble drugs attributed to high loading and surface-to-volume …
bioavailability of poorly water-soluble drugs attributed to high loading and surface-to-volume …
Drug-plasticizer interactions causing solid state transitions of rifaximin
K Höfler, E Littringer, A Pichler, S Scheler - International Journal of …, 2022 - Elsevier
Solid phase interactions are often the reason for incompatibilities in solid dosage forms. A
special situation occurs, if the incompatible compounds are able to migrate within the solid …
special situation occurs, if the incompatible compounds are able to migrate within the solid …