Protectins: Their biosynthesis, metabolism and structure-functions
Several lipoxygenase enzymes and cyclooxygenase-2 stereoselectively convert the
polyunsaturated fatty acids arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid …
polyunsaturated fatty acids arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid …
The protectin family of specialized pro-resolving mediators: potent immunoresolvents enabling innovative approaches to target obesity and diabetes
A western type diet and lifestyle play an important role in the development of chronic
diseases, yet little insight into the precise cellular and biomolecular mechanisms has …
diseases, yet little insight into the precise cellular and biomolecular mechanisms has …
Bioactive metabolites of docosahexaenoic acid
O Kuda - Biochimie, 2017 - Elsevier
Docosahexaenoic acid (DHA) is an essential fatty acid that is recognized as a beneficial
dietary constituent and as a source of the anti-inflammatory specialized proresolving …
dietary constituent and as a source of the anti-inflammatory specialized proresolving …
Stereoselective Construction of (E,Z)‐1,3‐Dienes and Its Application in Natural Product Synthesis
P Hubert, E Seibel, C Beemelmanns… - Advanced Synthesis …, 2020 - Wiley Online Library
Abstract The E, Z‐configured 1, 3‐diene unit is a common motif in numerous bioactive
natural products. Although several powerful methods are available to produce these motifs …
natural products. Although several powerful methods are available to produce these motifs …
Total Synthesis of the Lipid Mediator PD1n-3 DPA: Configurational Assignments and Anti-inflammatory and Pro-resolving Actions
The polyunsaturated lipid mediator PD1n-3 DPA (5) was recently isolated from self-resolving
inflammatory exudates of 5 and human macrophages. Herein, the first total synthesis of …
inflammatory exudates of 5 and human macrophages. Herein, the first total synthesis of …
Stereoselective Synthesis, Pro-resolution, and Anti-inflammatory Actions of RvD5n-3 DPA
K Ervik, AF Reinertsen, DS Koenis, J Dalli… - Journal of natural …, 2023 - ACS Publications
The methyl ester of resolvin D5n-3 DPA, a lipid mediator biosynthesized from the omega-3
fatty acid n-3 docosapentaenoic acid, was stereoselectively prepared in 8% yield over 12 …
fatty acid n-3 docosapentaenoic acid, was stereoselectively prepared in 8% yield over 12 …
[HTML][HTML] Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model
S Piao, W Du, Y Wei, Y Yang, X Feng, L Bai - International …, 2020 - Elsevier
Protectin DX (PDX) has been reported to have extensive anti-inflammatory effects. However,
it is unknown whether PDX acts as an anti-inflammatory agent in the context of osteoarthritis …
it is unknown whether PDX acts as an anti-inflammatory agent in the context of osteoarthritis …
Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid
Several novel oxygenated polyunsaturated lipid mediators biosynthesized from n-3
docosapentaenoic acid were recently isolated from murine inflammatory exudates and …
docosapentaenoic acid were recently isolated from murine inflammatory exudates and …
Metabolization of Resolvin E4 by ω-oxidation in human neutrophils: synthesis and biological evaluation of 20-Hydroxy-Resolvin E4 (20-OH-RvE4)
AF Reinertsen, S Libreros… - ACS Pharmacology & …, 2023 - ACS Publications
Resolvin E4 (RvE4) belongs to the resolvin family of specialized pro-resolving mediators
(SPMs). The resolvins are endogenously formed mediators with both potent pro-resolving …
(SPMs). The resolvins are endogenously formed mediators with both potent pro-resolving …
Total Synthesis of the Anti‐inflammatory and Pro‐resolving Lipid Mediator MaR1n−3 DPA Utilizing an sp3–sp3 Negishi Cross‐Coupling Reaction
JE Tungen, M Aursnes, J Dalli… - … A European Journal, 2014 - Wiley Online Library
The first total synthesis of the lipid mediator MaR1n− 3 DPA (5) has been achieved in 12%
overall yield over 11 steps. The stereoselective preparation of 5 was based on a Pd …
overall yield over 11 steps. The stereoselective preparation of 5 was based on a Pd …