We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

The omnigenic model was proposed as a framework to understand the highly polygenic
architecture of complex traits revealed by genome-wide association studies (GWASs). I …

In recent years, scientists have realized that evolution can occur on timescales much shorter
than the" long lapse of ages" emphasized by Darwin—in fact, evolutionary change is …

Non-additive genetic variance for complex traits is traditionally estimated from data on
relatives. It is notoriously difficult to estimate without bias in non-laboratory species …

We propose a method (GREML-LDMS) to estimate heritability for human complex traits in
unrelated individuals using whole-genome sequencing data. We demonstrate using …

The evidence that most adult-onset common diseases have a polygenic genetic architecture
fully consistent with robust biological systems supported by multiple back-up mechanisms is …

Genome-wide association studies (GWASs) have become the focus of the statistical analysis
of complex traits in humans, successfully shedding light on several aspects of genetic …

Individual differences in human intelligence, as assessed using cognitive test scores, have a
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …

Many diseases exhibit population-specific causal effect sizes with trans-ethnic genetic
correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We …

Many traits of interest are highly heritable and genetically complex, meaning that much of
the variation they exhibit arises from differences at numerous loci in the genome. Complex …