Current understanding of metal ions in the pathogenesis of Alzheimer's disease
L Wang, YL Yin, XZ Liu, P Shen, YG Zheng… - Translational …, 2020 - Springer
Background The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the
brain is crucial for maintaining normal physiological functions. Studies have shown that …
brain is crucial for maintaining normal physiological functions. Studies have shown that …
The biology of ergothioneine, an antioxidant nutraceutical
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …
Role of metal cations of copper, Iron, and aluminum and multifunctional ligands in Alzheimer's disease: Experimental and computational insights
Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people
around the world. Even though the causes of AD are not completely understood due to its …
around the world. Even though the causes of AD are not completely understood due to its …
Microglia and astrocytes in alzheimer's disease in the context of the aberrant copper homeostasis hypothesis
A Pal, I Rani, A Pawar, M Picozza, M Rongioletti… - Biomolecules, 2021 - mdpi.com
Evidence of copper's (Cu) involvement in Alzheimer's disease (AD) is available, but
information on Cu involvement in microglia and astrocytes during the course of AD has yet to …
information on Cu involvement in microglia and astrocytes during the course of AD has yet to …
Successful biosynthesis of natural antioxidant ergothioneine in Saccharomyces cerevisiae required only two genes from Grifola frondosa
YH Yu, HY Pan, LQ Guo, JF Lin, HL Liao, HY Li - Microbial Cell Factories, 2020 - Springer
Background Ergothioneine (EGT) has a unique antioxidant ability and diverse beneficial
effects on human health. But the content of EGT is very low in its natural producing …
effects on human health. But the content of EGT is very low in its natural producing …
Regulation of tyrosinase enzyme activity by glutathione peroxidase mimics
Hydrogen peroxide plays a crucial role in the melanogenesis process by regulating the
activity of the key melanin-forming enzyme tyrosinase, responsible for the browning of fruits …
activity of the key melanin-forming enzyme tyrosinase, responsible for the browning of fruits …
Interplay of the intermolecular and intramolecular interactions in stabilizing the thione-based copper (I) complexes and their significance in protecting the biomolecules …
The synthesis, characterization, and X-ray structure of a series of mono, tri, and polynuclear
copper complexes of benzimidazole-based N-substituted thiones, Bz Me SH (10) and Bz OH …
copper complexes of benzimidazole-based N-substituted thiones, Bz Me SH (10) and Bz OH …
Structural characterization and pharmacological assessment in vitro/in vivo of a new copper(ii)-based derivative of enrofloxacin
RF Guo, HT Yan, RX Liu, HC Li, YC Liu, ZF Chen… - Metallomics, 2020 - academic.oup.com
Enrofloxacin (EFX) was selected as the medicinal ligand to afford a new copper (ii)-based
complex, EFX-Cu, which was structurally characterized by spectroscopic analyses including …
complex, EFX-Cu, which was structurally characterized by spectroscopic analyses including …
Synthesis, structures and DFT study of copper coordination with bis-benzimidazole based thiones and selones: Scope for nonstoichiometric Cu2-xSe nanoparticles
The newly synthesized benzimidazole-based [E2]-donor ligands (E= S or Se)(L1− L4) on
reaction with copper (II) chloride and copper (II) acetate involved reduction of Cu (II) to Cu (I) …
reaction with copper (II) chloride and copper (II) acetate involved reduction of Cu (II) to Cu (I) …
Coordination complexes of methimazole with copper: Controlling redox reactions and sulfur extrusion
JM Murphy, AAE Gaertner, AM Owen, S Struder… - Inorganica Chimica …, 2020 - Elsevier
Sulfur-containing imidazole thiones are of interest for their redox chemistry and tendency to
form disulfide bonds reminiscent of biologically active disulfides. Treating copper (II) with …
form disulfide bonds reminiscent of biologically active disulfides. Treating copper (II) with …