Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites
and has been proposed to regulate transcription initiation,. However, redundant functions of …

Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome.
Although the translation of circRNAs was reported, additional coding circRNAs and the …

Gene regulation involves activation of RNA polymerase II (Pol II) that is paused and bound
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent
kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing …

The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …

INTRODUCTION RNA cleavage and phosphorylation-dephosphorylation of the RNA
polymerase II (Pol II) C-terminal domain (CTD) are two regulatory mechanisms of …

Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor
characterized by rapid and uniform patient demise. A heterozygous point mutation of histone …