Understanding how individual neurons integrate the thousands of synaptic inputs they
receive is critical to understanding how the brain works. Modeling studies in silico and …

Calcium ions generate versatile intracellular signals that control key functions in all types of
neurons. Imaging calcium in neurons is particularly important because calcium signals exert …

The brain has an extraordinary capacity for memory storage, but how it stores new
information without disrupting previously acquired memories remains unknown. Here we …

Genetically encoded calcium indicators (GECIs) are powerful tools for systems
neuroscience. Here we describe red, single-wavelength GECIs,“RCaMPs,” engineered from …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

Long-term potentiation (LTP) in the CA1 region of the hippocampus has been the primary
model by which to study the cellular and molecular basis of memory. Calcium/calmodulin …

The role of back-propagating dendritic action potentials in the induction of long-term
potentiation (LTP) was investigated in CA1 neurons by means of dendritic patch recordings …

THE dendrites of neurons in the mammalian central nervous system have been considered
as electrically passive structures which funnel synaptic potentials to the soma and axon …

Pyramidal neurons receive tens of thousands of synaptic inputs on their dendrites. The
dendrites dynamically alter the strengths of these synapses and coordinate them to produce …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …