Divalent cations: a molecular glue for protein materials

H López-Laguna, J Sánchez, U Unzueta… - Trends in biochemical …, 2020 - cell.com
Among inorganic materials, divalent cations modulate thousands of physiological processes
that support life. Their roles in protein assembly and aggregation are less known, although …

Development of the peritoneal metastasis: a review of back-grounds, mechanisms, treatments and prospects

K Ren, X Xie, T Min, T Sun, H Wang, Y Zhang… - Journal of Clinical …, 2022 - mdpi.com
Peritoneal metastasis is a malignant disease which originated from several gastrointestinal
and gynecological carcinomas and has been leading to a suffering condition in patients for …

[HTML][HTML] Protein features instruct the secretion dynamics from metal-supported synthetic amyloids

E Parladé, JM Sánchez, H López-Laguna… - International journal of …, 2023 - Elsevier
Hexahistidine-tagged proteins can be clustered by divalent cations into self-containing,
dynamic protein depots at the microscale, which under physiological conditions leak …

Probing the Biosafety of Implantable Artificial Secretory Granules for the Sustained Release of Bioactive Proteins

P Álamo, E Parladé, MTP Favaro… - … applied materials & …, 2023 - ACS Publications
Among bio-inspired protein materials, secretory protein microparticles are of clinical interest
as self-contained, slow protein delivery platforms that mimic secretory granules of the human …

Biofabrication of functional protein nanoparticles through simple His-tag engineering

H López-Laguna, JM Sanchez… - ACS sustainable …, 2021 - ACS Publications
We have developed a simple, robust, and fully transversal approach for the a-la-carte
fabrication of functional multimeric nanoparticles with potential biomedical applications …

[HTML][HTML] Protein scaffolds in human clinics

O Cano-Garrido, N Serna, U Unzueta, E Parladé… - Biotechnology …, 2022 - Elsevier
Fundamental clinical areas such as drug delivery and regenerative medicine require
biocompatible materials as mechanically stable scaffolds or as nanoscale drug carriers …

[HTML][HTML] Multifunctional antibody-conjugated coiled-coil protein nanoparticles for selective cell targeting

M Gil-Garcia, S Ventura - Acta Biomaterialia, 2021 - Elsevier
Nanostructures decorated with antibodies (Abs) are applied in bioimaging and therapeutics.
However, most covalent conjugation strategies affect Abs functionality. In this study, we …

Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids

JM Sánchez, H López‐Laguna, E Parladé… - Advanced …, 2024 - Wiley Online Library
Developing time‐sustained drug delivery systems is a main goal in innovative medicines.
Inspired by the architecture of secretory granules from the mammalian endocrine system it …

A near‐infrared probe for detecting and interposing amyloid beta oligomerization in early Alzheimer's disease

L Quan, I Moreno‐Gonzalez, Z Xie… - Alzheimer's & …, 2023 - Wiley Online Library
Background The misfolding and deposition of amyloid beta (Aβ) in human brain is the main
hallmark of Alzheimer's disease (AD) pathology. One of the drivers of Alzheimer´ s …

Recombinant Proteins for Assembling as Nano-and Micro-Scale Materials for Drug Delivery: A Host Comparative Overview

JL Corchero, MTP Favaro, M Márquez-Martínez… - Pharmaceutics, 2023 - mdpi.com
By following simple protein engineering steps, recombinant proteins with promising
applications in the field of drug delivery can be assembled in the form of functional materials …