PDZ domains are abundant protein interaction modules that often recognize short amino
acid motifs at the C-termini of target proteins. They regulate multiple biological processes …

Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions …

The Notch signaling pathway regulates a diverse array of cell types and cellular processes
and is tightly regulated by ligand binding. Both canonical and noncanonical Notch ligands …

Despite high expression levels at the plasma membrane or in intracellular vesicles,
tetraspanins remain among the most mysterious transmembrane molecules 20 years after …

Cystic fibrosis transmembrane conductance regulator (CFTR), a Cl−-selective ion channel,
is a prototypic member of the ATP-binding cassette transporter superfamily that is expressed …

Heme serves as a co-factor in proteins involved in fundamental biological processes
including oxidative metabolism, oxygen storage and transport, signal transduction and drug …

NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal
proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a …

The intestinal and renal proximal tubule brush border (BB) Na+–H+ exchanger NHE3 binds
to members of the NHERF (Na+–H+ exchanger regulatory factor) family. These are four …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated
chloride channel located primarily at the apical or luminal surfaces of epithelial cells in the …

Cystic fibrosis (CF) is the most common genetic disorder that causes a significant damage in
secretory epithelial cells due to the defective ion flux across the cystic fibrosis …