Publisher Summary This chapter reviews that DNA is the principal target molecule for
neutral platinum complexes in a variety of biological systems. The most convincing …

Abstract Cis-diamminedichloroplatinum (II)(c-DDP), a highly effective cytostatic drug, is
increasingly used in combination with irradiation both in the laboratory and in patients. This …

PURPOSE The Southwest Oncology Group (SWOG) coordinated an Intergroup study with
the participation of Radiation Therapy Oncology Group (RTOG), and Eastern Cooperative …

PURPOSE: To test the hypothesis that cisplatin (CDDP) administered concurrently with
standard radiotherapy (RT) would improve pelvic control and survival in patients with …

Cancer treatment with ionizing radiation (IR) is a well-established and effective clinical
method to fight different types of tumors and is a palliative treatment to cure metastatic …

In patients who have locally advanced and inoperable head and neck cancer, the
achievement of initial local control (complete response) of the disease with initial definitive …

The results of radiotherapy alone for patients with locally advanced (stage III or IV)
nasopharyngeal cancer (NPC) are poor in spite of the initial complete clearance. Twenty …

PURPOSE Patients with locally advanced inoperable non-small-cell lung cancer (NSCLC)
have a poor clinical outcome. We conducted a prospective study to evaluate the merit of …

A rationale for coordinating the administration of carboplatin with radiation to achieve
enhancement of cancer therapy is developed. This approach is based upon a review of the …

Abstract Cis-dichlorodiammineplatinum (II), or cis-PDD, has recently been shown to be a
potent radiosensitizer of bacteria, particularly under conditions of acute hypoxia. This study …