Pathophysiology of hypoxic–ischemic encephalopathy: a review of the past and a view on the future

P Greco, G Nencini, I Piva, M Scioscia, CA Volta… - Acta Neurologica …, 2020 - Springer
Hypoxic–ischemic encephalopathy, also referred as HIE, is a type of brain injury or damage
that is caused by a lack of oxygen to the brain during neonatal period. The incidence is …

New possibilities for neuroprotection in neonatal hypoxic-ischemic encephalopathy

S Victor, E Rocha-Ferreira, A Rahim, H Hagberg… - European journal of …, 2022 - Springer
Around 0.75 million babies worldwide suffer from moderate or severe hypoxic-ischemic
encephalopathy (HIE) each year resulting in around 400,000 babies with …

Neuroimaging in the term newborn with neonatal encephalopathy

JL Wisnowski, P Wintermark, SL Bonifacio… - Seminars in Fetal and …, 2021 - Elsevier
Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates
with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few …

Hypoxic-ischemic encephalopathy: pathogenesis and promising therapies

M Yang, K Wang, B Liu, Y Shen, G Liu - Molecular neurobiology, 2024 - Springer
Hypoxic-ischemic encephalopathy (HIE) is a brain lesion caused by inadequate blood
supply and oxygen deprivation, often occurring in neonates. It has emerged as a grave …

Neuroprotective therapies in the NICU in term infants: present and future

EJ Molloy, M El-Dib, SE Juul, M Benders… - Pediatric …, 2023 - nature.com
Outcomes of neonatal encephalopathy (NE) have improved since the widespread
implementation of therapeutic hypothermia (TH) in high-resource settings. While TH for NE …

A pilot phase i trial of allogeneic umbilical cord tissue-derived mesenchymal stromal cells in neonates with hypoxic-ischemic encephalopathy

CM Cotten, K Fisher, W Malcolm… - Stem Cells …, 2023 - academic.oup.com
Hypoxic ischemic encephalopathy (HIE) in neonates causes increased mortality and long-
term morbidity in surviving babies. Hypothermia (HT) has improved outcomes, however …

Therapies for neonatal encephalopathy: Targeting the latent, secondary and tertiary phases of evolving brain injury

AA Chakkarapani, H Aly, M Benders, CM Cotten… - Seminars in Fetal and …, 2021 - Elsevier
In term and near-term neonates with neonatal encephalopathy, therapeutic hypothermia
protocols are well established. The current focus is on how to improve outcomes further and …

Sex differences in neonatal brain injury and inflammation

LA Kelly, A Branagan, G Semova… - Frontiers in Immunology, 2023 - frontiersin.org
Neonatal brain injury and associated inflammation is more common in males. There is a well-
recognised difference in incidence and outcome of neonatal encephalopathy according to …

[HTML][HTML] A narrative review on treatment strategies for neonatal hypoxic ischemic encephalopathy

JM Korf, LD McCullough, V Caretti - Translational Pediatrics, 2023 - ncbi.nlm.nih.gov
Methods We included full articles and book chapters published in English on PubMed with
references to “hypoxic ischemic encephalopathy”,“birth asphyxia”,“therapeutic hypothermia” …

Neonatal asphyxia as an inflammatory disease: reactive oxygen species and cytokines

K Okazaki, S Nakamura, K Koyano, Y Konishi… - Frontiers in …, 2023 - frontiersin.org
Neonatologists resuscitate asphyxiated neonates by every available means, including
positive ventilation, oxygen therapy, and drugs. Asphyxiated neonates sometimes present …