Stem cells exist as normal cells in embryonic and adult tissues. In recent years, scientists
have spared efforts to determine the role of stem cells in treating many diseases. Stem cells …

Cardiovascular disease is still one of the leading causes of death in the world, and heart
transplantation is the current major treatment for end-stage cardiovascular diseases …

Ependymoma is a heterogeneous entity of central nervous system tumors with well-
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …

Transposable elements (TEs) make up a majority of a typical eukaryote's genome, and
contribute to cell heterogeneity in unclear ways. Single-cell sequencing technologies are …

The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …

Human pluripotent embryonic stem cells have two special features: self-renewal and
pluripotency. It is important to understand the properties of pluripotent stem cells and …

Cell fate is likely regulated by a common machinery, while components of this machine
remain to be identified. Here we report the design and testing of engineered cell fate …

Organismal aging is inherently connected to the aging of its constituent cells and systems.
Reducing the biological age of the organism may be assisted by reducing the age of its cells …

Cell fate decision involves rewiring of the genome, but remains poorly understood at the
chromatin level. Here, we report that chromatin remodeling complex NuRD participates in …

Embryonic stem cells (ESCs) are a type of cells capable of self-renewal and multi-directional
differentiation. The self-renewal of ESCs is regulated by factors including signaling pathway …