Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …

Pulmonary fibrosis (PF) is characterized by aberrant extracellular matrix (ECM) deposition,
activation of fibroblasts to myofibroblasts and parenchymal disorganization, which have an …

Idiopathic pulmonary fibrosis (IPF) is a progressive and devastating lung disorder of
unknown origin, with very poor prognosis and no effective treatment. The disease is …

In the lungs, fibrosis is a growing clinical problem that results in shortness of breath and can
end up in respiratory failure. Even though the main fibrotic disease affecting the lung is …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with incompletely understood aetiology
and limited treatment options. Traditionally, IPF was believed to be mainly caused by …

Abstract Background Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs
(TIMPs) play important roles in the turnover of extracellular matrix and in the pathogenesis of …

Pulmonary fibrosis results from a plethora of abnormal pathogenetic events. In idiopathic
pulmonary fibrosis (IPF), inhalational, environmental, or occupational exposures in …

The extracellular matrix (ECM) is a complex network of proteins and proteoglycans secreted
by keratinocytes, fibroblasts and immune cells. The function of the skin ECM has expanded …

Tissue remodeling/fibrosis is a major feature of all fibrotic diseases, including idiopathic
pulmonary fibrosis (IPF). It is underpinned by accumulating extracellular matrix (ECM) …

Disease behaviour in interstitial lung disease (ILD) is highly variable and accurate clinical
tools to predict prognosis and guide management decisions remain unsatisfactorily elusive …