Gut microbiota, immune system, and bone

P D'Amelio, F Sassi - Calcified tissue international, 2018 - Springer
The gut microbiota (GM) is the whole of commensal, symbiotic, and pathogenic
microorganisms living in our intestine. The GM–host interactions contribute to the maturation …

Linking the microbiota, chronic disease, and the immune system

TW Hand, I Vujkovic-Cvijin, VK Ridaura… - Trends in Endocrinology & …, 2016 - cell.com
Chronic inflammatory diseases (CIDs) are the most important causes of mortality in the world
today and are on the rise. We now know that immune-driven inflammation is critical in the …

Sparse and compositionally robust inference of microbial ecological networks

ZD Kurtz, CL Müller, ER Miraldi… - PLoS computational …, 2015 - journals.plos.org
16S ribosomal RNA (rRNA) gene and other environmental sequencing techniques provide
snapshots of microbial communities, revealing phylogeny and the abundances of microbial …

IgA-coated E. coli enriched in Crohn's disease spondyloarthritis promote TH17-dependent inflammation

M Viladomiu, C Kivolowitz, A Abdulhamid… - Science translational …, 2017 - science.org
Peripheral spondyloarthritis (SpA) is a common extraintestinal manifestation in patients with
active inflammatory bowel disease (IBD) characterized by inflammatory enthesitis, dactylitis …

Impact of gut microbiota on diabetes mellitus

G Blandino, R Inturri, F Lazzara, M Di Rosa… - Diabetes & …, 2016 - Elsevier
Various functions of the gut are regulated by sophisticated interactions among its functional
elements, including the gut microbiota. These microorganisms play a crucial role in …

Microbiota in T-cell homeostasis and inflammatory diseases

N Lee, WU Kim - Experimental & molecular medicine, 2017 - nature.com
The etiology of disease pathogenesis can be largely explained by genetic variations and
several types of environmental factors. In genetically disease-susceptible individuals …

Evaluating the causal role of gut microbiota in type 1 diabetes and its possible pathogenic mechanisms

H Zhou, L Sun, S Zhang, X Zhao, X Gang… - Frontiers in …, 2020 - frontiersin.org
Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic,
epigenetic, and environmental factors. In recent years, the emergence of high-throughput …

T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases

H González, R Pacheco - Journal of neuroinflammation, 2014 - Springer
Neuroinflammation is involved in several neurodegenerative disorders and emerging
evidence indicates that it constitutes a critical process that is required for the progression of …

Immunoresponsive microbiota-gut-on-chip reproduces barrier dysfunction, stromal reshaping and probiotics translocation under inflammation

V De Gregorio, C Sgambato, F Urciuolo, R Vecchione… - Biomaterials, 2022 - Elsevier
Here, we propose an immune-responsive human Microbiota-Intestine axis on-chip as a
platform able to reproduce the architecture and vertical topography of the microbiota with a …

Single delivery of high-diversity fecal microbiota preparation by colonoscopy is safe and effective in increasing microbial diversity in active ulcerative colitis

V Jacob, C Crawford… - Inflammatory bowel …, 2017 - academic.oup.com
Background Recent trials suggest fecal microbiota transplantation (FMT) with repeated
enemas and high-diversity FMT donors is a promising treatment to induce remission in …