The ability of skin to act as a barrier is primarily determined by cells that maintain the
continuity and integrity of skin and restore it after injury. Cutaneous wound healing in adult …

Basement membranes are widely distributed extracellular matrices that coat the basal
aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells …

Laminin, as a key component of the basement membrane extracellular matrix (ECM),
regulates tissue morphogenesis. Here, we show that multiple laminin isoforms …

The laminins are a family of glycoproteins that provide an integral part of the structural
scaffolding of basement membranes in almost every animal tissue. Each laminin is a …

▪ Abstract Significant advances have been made in the application of genetics to probe the
functions of basement membrane laminins. These studies have shown that different laminin …

Laminin 332 is crucial in the biology of epithelia. This large extracellular matrix protein
consists of the heterotrimeric assembly of three subunits–α3, β3, and γ2–and its …

The attachment of cells to the extracellular matrix is of crucial importance in the maintenance
of tissue structure and integrity. In stratified epithelia such as in skin as well as in other …

The epidermis functions in skin as first defense line or barrier against environmental
impacts, resting on extracellular matrix (ECM) of the dermis underneath. Both compartments …

Extracellular matrix (ECM) is known to provide signals controlling cell shape, migration,
proliferation, differentiation, morphogenesis, and survival. Recent data shows that some of …

The extracellular matrix is not merely a passive structure. In the past few years, it has
emerged that the matrix is a dynamic action zone that functions to instruct cellular …