Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

In addition to endocytosis-mediated cellular uptake, hydrophilic cell-penetrating peptides
are able to traverse biological membranes in a non-endocytic mode termed transduction …

Endocytosis has been implicated in the cellular uptake of arginine-rich, cell-penetrating
peptides (CPPs). However, accumulating evidence suggests that certain conditions allow …

Research into the mechanism of protein transduction has undergone a renaissance in the
past five years as many groups have sought to understand the behavior of transducing …

Cell-penetrating peptides (CPPs) traverse the membrane of biological cells at low
micromolar concentrations and are able to take various cargo molecules along with. Despite …

Delineating the mechanisms by which cell-penetrating peptides, such as HIV-Tat peptide,
oligoarginines and penetratin, gain access to cells has recently received intense scrutiny …

There is some overlap in the biological activities of cell-penetrating peptides (CPPs) and
antimicrobial peptides (AMPs). We compared nine AMPs, seven CPPs, and a fusion peptide …

The insertion of charged amino acid residues into the hydrophobic part of lipid bilayers is
energetically unfavorable yet found in many cationic membrane peptides and protein …