The SCF (Skp1–Cullin–F-box) E3 ubiquitin ligase family was discovered through genetic
requirements for cell cycle progression in budding yeast. In these multisubunit enzymes, an …

Since the discovery of a single white‐eyed male in a population of red eyed flies over 100
years ago (Morgan, 1910), the compound eye of the fruit fly, Drosophila melanogaster, has …

Drosophila melanogaster is a proven model system for many aspects of human biology.
Here we present a two-hybrid–based protein-interaction map of the fly proteome. A total of …

The Ras and Notch signaling pathways are used over and over again during development
to control many different biological processes. Frequently, these two signaling pathways …

Enteroendocrine cells (EECs) in both invertebrates and vertebrates derive from intestinal
stem cells (ISCs) and are scattered along the digestive tract, where they function in sensing …

Petunia inflata S-locus F-box (Pi SLF) is thought to function as a typical F-box protein in
ubiquitin-mediated protein degradation and, along with Skp1, Cullin-1, and Rbx1, could …

Growing evidence indicates that ubiquitin ligases play a critical role in the hypoxia response.
Among them, Siah2, a RING finger ligase, is an important regulator of pathways activated …

The Drosophila eye is a highly ordered epithelial tissue composed of∼ 750 subunits called
ommatidia arranged in a reiterated hexagonal pattern. At higher resolution, observation of …

The ubiquitin ligase Siah2 has been shown to regulate prolyl hydroxylase 3 (PHD3) stability
with concomitant effect on HIF-1α availability. Because HIF-1α is implicated in tumorigenesis …

The Drosophila SINA (seven in absentia) protein and its mammalian orthologs (Siah, seven
in absentia homolog) are RING domain proteins that function in E3 ubiquitin ligase …