Proliferation and activation of microglia in the brain, concentrated around amyloid plaques,
is a prominent feature of Alzheimer's disease (AD). Human genetics data point to a key role …

Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

Microglia play critical roles in brain development, homeostasis, and neurological disorders.
Here, we report that human microglial-like cells (iMGLs) can be differentiated from iPSCs to …

Alzheimer's disease (AD) is one of the most common types of age-related dementia
worldwide. In addition to extracellular amyloid plaques and intracellular neurofibrillary …

Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of
the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Genome-wide association studies (GWAS) originally identified ATP-binding cassette, sub-
family A, member 7 (ABCA7), as a novel risk gene of Alzheimer's disease (AD). Since then …

Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …

Overexpression of ATP-binding cassette (ABC) transporters is a cause of drug resistance in
a plethora of tumors. More recent evidence indicates additional contribution of these …

Alzheimer's disease (AD) is the leading cause of dementia in the United States and afflicts>
5.7 million Americans in 2018. Therapeutic options remain extremely limited to those that …