The S100B story: from biomarker to active factor in neural injury

F Michetti, N D'Ambrosi, A Toesca… - Journal of …, 2019 - Wiley Online Library
S100B is a Ca2+‐binding protein mainly concentrated in astrocytes. Its levels in biological
fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are …

S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles

R Donato - The international journal of biochemistry & cell biology, 2001 - Elsevier
S100 is a multigenic family of non-ubiquitous Ca2+-modulated proteins of the EF-hand type
expressed in vertebrates exclusively and implicated in intracellular and extracellular …

Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease

MW Berchtold, H Brinkmeier… - Physiological …, 2000 - journals.physiology.org
Mammalian skeletal muscle shows an enormous variability in its functional features such as
rate of force production, resistance to fatigue, and energy metabolism, with a wide spectrum …

Intracellular and extracellular roles of S100 proteins

R Donato - Microscopy research and technique, 2003 - Wiley Online Library
S100, a multigenic family of non‐ubiquitous Ca2+‐modulated proteins of the EF‐hand type
expressed in vertebrates exclusively, has been implicated in intracellular and extracellular …

S100B in brain damage and neurodegeneration

M Rothermundt, M Peters, JHM Prehn… - … research and technique, 2003 - Wiley Online Library
S100B is a calcium‐binding peptide produced mainly by astrocytes that exert paracrine and
autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and …

[HTML][HTML] Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type

R Donato - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 1999 - Elsevier
A multigenic family of Ca2+-binding proteins of the EF-hand type known as S100 comprises
19 members that are differentially expressed in a large number of cell types. Members of this …

Calcium-dependent and-independent interactions of the S100 protein family

L Santamaria-Kisiel, AC Rintala-Dempsey… - Biochemical …, 2006 - portlandpress.com
The S100 proteins comprise at least 25 members, forming the largest group of EF-hand
signalling proteins in humans. Although the proteins are expressed in many tissues, each …

The S100B protein in biological fluids: more than a lifelong biomarker of brain distress

F Michetti, V Corvino, MC Geloso… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 644–659. Abstract S100B is a calcium‐binding protein
concentrated in glial cells, although it has also been detected in definite extra‐neural cell …

Dedicated myosin light chain kinases with diverse cellular functions

KE Kamm, JT Stull - Journal of Biological Chemistry, 2001 - ASBMB
Cell signaling events that lead to increased [Ca2+] i 1 in smooth and skeletal muscles
activate Ca2+/calmodulin-dependent MLCK. The kinase phosphorylates a specific site on …

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

T Centner, J Yano, E Kimura, AS McElhinny… - Journal of molecular …, 2001 - Elsevier
The giant myofibrillar protein titin contains within its C-terminal region a serine-threonine
kinase of unknown function. We have identified a novel muscle specific RING finger protein …