Phenotypic approaches to obstructive sleep apnoea–new pathways for targeted therapy

DJ Eckert - Sleep medicine reviews, 2018 - Elsevier
People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Personalized management approach for OSA

JC Carberry, J Amatoury, DJ Eckert - Chest, 2018 - Elsevier
OSA is a heterogeneous disorder. If left untreated, it has major health, safety, and economic
consequences. In addition to varying levels of impairment in pharyngeal anatomy …

Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets

DJ Eckert, DP White, AS Jordan, A Malhotra… - American journal of …, 2013 - atsjournals.org
Rationale: The pathophysiologic causes of obstructive sleep apnea (OSA) likely vary among
patients but have not been well characterized. Objectives: To define carefully the proportion …

[HTML][HTML] The difficult airway with recommendations for management–part 2–the anticipated difficult airway

JA Law, N Broemling, RM Cooper, P Drolet… - Canadian Journal of …, 2013 - ncbi.nlm.nih.gov
Background Appropriate planning is crucial to avoid morbidity and mortality when difficulty is
anticipated with airway management. Many guidelines developed by national societies have …

Supine position related obstructive sleep apnea in adults: pathogenesis and treatment

SA Joosten, DM O'Driscoll, PJ Berger… - Sleep medicine reviews, 2014 - Elsevier
The most striking feature of obstructive respiratory events is that they are at their most severe
and frequent in the supine sleeping position: indeed, more than half of all obstructive sleep …

Upper airway collapsibility (Pcrit) and pharyngeal dilator muscle activity are sleep stage dependent

JC Carberry, AS Jordan, DP White, A Wellman… - Sleep, 2016 - academic.oup.com
Abstract Study Objectives: An anatomically narrow/highly collapsible upper airway is the
main cause of obstructive sleep apnea (OSA). Upper airway muscle activity contributes to …

[HTML][HTML] A review of supine position related obstructive sleep apnea: classification, epidemiology, pathogenesis and treatment

SA Landry, C Beatty, LDJ Thomson, AM Wong… - Sleep Medicine …, 2023 - Elsevier
Supine related obstructive sleep apnea (OSA) is the most common clinical and physiological
phenotype of OSA. This condition is recognizable by patients, their families and through …

Critical to know Pcrit: a review on pharyngeal critical closing pressure in obstructive sleep apnea

E Kazemeini, E Van de Perck, M Dieltjens… - Frontiers in …, 2022 - frontiersin.org
It is crucial to understand the underlying pathophysiology of obstructive sleep apnea (OSA).
Upper airway collapsibility is an important pathophysiological factor that affects the upper …

Biomechanical properties of the human upper airway and their effect on its behavior during breathing and in obstructive sleep apnea

LE Bilston, SC Gandevia - Journal of applied physiology, 2014 - journals.physiology.org
The upper airway is a complex, multifunctional, dynamic neuromechanical system. Its
patency during breathing requires moment-to-moment coordination of neural and …

Analysis of the influence of head rotation during drug‐induced sleep endoscopy in obstructive sleep apnea

F Safiruddin, I Koutsourelakis, N de Vries - The Laryngoscope, 2014 - Wiley Online Library
Objectives/Hypothesis Currently, drug‐induced sleep endoscopy (DISE) in obstructive sleep
apnea (OSA) is predominantly performed in supine position. When positional therapy …