Glutathione (GSH) is the most abundant non-protein thiol present at millimolar
concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a …

Occupational or environmental exposures to heavy metals produce several adverse health
effects. The common mechanism determining their toxicity and carcinogenicity is the …

Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as
a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a …

It has been established that oxidative stress, defined as the condition in which the sum of
free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the …

ABC transporters constitute one of the largest protein families found in all living organisms.
ABC transporters are driven by ATP hydrolysis and can act as exporters as well as …

Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …

In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …

The human multidrug resistance-associated protein (MRP) family currently has seven
members. The ability of several of these membrane proteins to transport a wide range of …

The glutathione (GSH) content of cancer cells is particularly relevant in regulating mutagenic
mechanisms, DNA synthesis, growth, and multidrug and radiation resistance. In malignant …