Methotrexate (MTX) is significantly more effective than and has a considerable advantage
over placebo in patients with severe and persistent rheumatoid arthritis (RA). The drug is …

Immune checkpoint inhibitors (ICIs) are effective in the treatment of patients with advanced
cancer and have emerged as a pillar of standard cancer care. However, their use is …

Background Increases in lipid levels and cancers with tofacitinib prompted a trial of major
adverse cardiovascular events (MACE) and cancers in patients with rheumatoid arthritis …

Background Rheumatoid arthritis is the most common autoimmune disease worldwide and
requires long-term treatment to suppress inflammation. Currently, treatment is started when …

Importance Proactive therapeutic drug monitoring (TDM), defined as individualized drug
dosing based on scheduled monitoring of serum drug levels, has been proposed as an …

Objectives To evaluate malignancies and their associations with baseline risk factors and
cardiovascular risk scores with tofacitinib versus tumour necrosis factor inhibitors (TNFi) in …

The inception of cancer treatment with chemotherapeutics began in the 1940s with nitrogen
mustards that were initially employed as weapons in World War II. Since then, treatment …

One of the prominent complications observed in those undergoing treatment with
methotrexate (MTX) is hematological profile alterations which could culminate in severe …

Mesenchymal stem cells (MSCs) have great potential to differentiate into various types of
cells, including but not limited to, adipocytes, chondrocytes and osteoblasts. In addition to …

Active neutrophils participate in innate and adaptive immune responses through various
mechanisms, one of the most important of which is the formation and release of neutrophil …