Many species of African nonhuman primates are naturally infected with simian
immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected …

In this article, we summarize the role of CD8+ T cells during natural and antiretroviral
therapy (ART)‐treated HIV and SIV infections, discuss the mechanisms responsible for their …

Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus
replication. Strikingly, it is characterized by low levels of immune activation, while …

Chronic immune activation and progression to AIDS are observed after SIV infection in
macaques but not in natural host primate species. To better understand this dichotomy, we …

Pathogenic HIV infections of humans and simian immunodeficiency virus (SIV) infections of
rhesus macaques are characterized by generalized immune activation and progressive …

The mechanisms by which HIV induces the immune dysfunction clinically defined as AIDS
have been a subject of intense study since the discovery of the virus in the early 1980s …

Disease-free infection in HIV-infected adults is associated with human leukocyte antigen–
mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural …

Human immunodeficiency virus (HIV)-1 infection causes progressive impairment of the
immune system in humans, characterized by depletion of CD4 T cells and loss of T cell …

HIV-infected humans and SIV-infected rhesus macaques experience a rapid and dramatic
loss of mucosal CD4+ T cells that is considered to be a key determinant of AIDS …

In striking contrast to HIV infection, natural SIV infection of African nonhuman primates is
asymptomatic and usually does not induce significant CD4+ T cell depletion despite high …