Ethnopharmacological relevance Saffron, the dried red stigma of the perennial herb Crocus
sativus L.(Iridaceae), is one of the most important and expensive spices in the world. It is …

Chronic stress and high levels of glucocorticoids produce functional and structural changes
in brain and especially in the hippocampus, an important limbic system structure that plays a …

Objectives Recently, a great deal of interest has been developed to isolate and investigate
novel bioactive components from natural resources with health beneficial effects. Saffron is …

Alzheimer's disease (AD) is the most common form of dementia, in which the death of brain
cells causes memory loss and cognitive decline. Several factors are thought to play roles in …

Crocus sativus L.(Saffron) has long been known for multiple target therapeutic uses. The
plant metabolism is well investigated and the main metabolites related to saffron …

The increasing morbidity rates of brain disorders and conditions such as anxiety,
depression, Alzheimer's disease, and Parkinson's disease have become a severe problem …

Cognitive decline can occur with normal ageing and in age‐related brain disorders, such as
mild cognitive impairment and dementia, including Alzheimer's disease, with limited …

Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 (COVID-19), came as a
significant health care challenge for humans in 2019–20. Based on recent laboratory and …

Crocus sativus L.(saffron) appears to own neuroprotective effects on cognitive impairment in
patients with Alzheimer's disease (AD). The purpose of this work is to review evidence and …

Anxiety disorders and schizophrenia are common public health issues. The dried stigma of
the plant Crocus sativus L.,(C. sativus) commonly known as saffron are used in folk medicine …