The impact of next-generation sequencing (NGS) cannot be overestimated. The technology
has transformed the field of life science, contributing to a dramatic expansion in our …

Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their
flexible organization and functional redundancies make deciphering their sequence-function …

Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

Divergence of cis-regulatory elements drives species-specific traits, but how this manifests in
the evolution of the neocortex at the molecular and cellular level remains unclear. Here we …

Heliconius butterflies, a speciose genus of Müllerian mimics, represent a classic example of
an adaptive radiation that includes a range of derived dietary, life history, physiological and …

Sequence-based machine learning models trained on genome-scale biochemical assays
improve our ability to interpret genetic variants by providing functional predictions describing …

This paper considers how a classification of causal effects as comprising efficient, formal,
material, and final causation can provide a useful understanding of how emergence takes …

Vocal production learning (“vocal learning”) is a convergently evolved trait in vertebrates. To
identify brain genomic elements associated with mammalian vocal learning, we integrated …

Mammal genomics has progressed at an uneven pace—half sloth, half cheetah—owing to
various technical obstacles, including the complexity of eukaryotic genomes, difficulties …