New angiogenic regulators produced by TAMs: perspective for targeting tumor angiogenesis

I Larionova, E Kazakova, T Gerashchenko… - Cancers, 2021 - mdpi.com
Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

Joining S100 proteins and migration: for better or for worse, in sickness and in health

SR Gross, CGT Sin, R Barraclough… - Cellular and molecular life …, 2014 - Springer
The vast diversity of S100 proteins has demonstrated a multitude of biological correlations
with cell growth, cell differentiation and cell survival in numerous physiological and …

Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell …

PR Gielen, BM Schulte, ED Kers-Rebel… - Neuro …, 2016 - academic.oup.com
Background Gliomas are primary brain tumors that are associated with a poor prognosis.
The introduction of new treatment modalities (including immunotherapy) for these …

Serum of post-COVID-19 syndrome patients with or without ME/CFS differentially affects endothelial cell function in vitro

L Flaskamp, C Roubal, S Uddin, F Sotzny, C Kedor… - Cells, 2022 - mdpi.com
A proportion of COVID-19 reconvalescent patients develop post-COVID-19 syndrome (PCS)
including a subgroup fulfilling diagnostic criteria of Myalgic encephalomyelitis/Chronic …

Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8

GO Ahn, J Seita, BJ Hong, YE Kim… - Proceedings of the …, 2014 - National Acad Sciences
Emerging evidence indicates that myeloid cells are essential for promoting new blood
vessel formation by secreting various angiogenic factors. Given that hypoxia-inducible factor …

The functions and regulatory pathways of S100A8/A9 and its receptors in cancers

H Zhou, C Zhao, R Shao, Y Xu, W Zhao - Frontiers in Pharmacology, 2023 - frontiersin.org
Inflammation primarily influences the initiation, progression, and deterioration of many
human diseases, and immune cells are the principal forces that modulate the balance of …

The S100 protein family in lung cancer

T Wang, G Du, D Wang - Clinica Chimica Acta, 2021 - Elsevier
The S100 protein family is involved in the pathogenesis of several malignancies including
lung cancer. Recent studies have shown that one member, S100A2, was over-expressed in …

S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/β-catenin …

L Duan, R Wu, L Ye, H Wang, X Yang, Y Zhang… - PloS one, 2013 - journals.plos.org
Background and Objective S100A8 and S100A9, two members of the S100 protein family,
have been reported in association with the tumor cell differentiation and tumor progression …

S100A8/A9hi neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis

Y Wang, Y Shi, Y Shao, X Lu, H Zhang, C Miao - Cell Death & Disease, 2024 - nature.com
Abstract S100a8/a9, largely released by polymorphonuclear neutrophils (PMNs), belongs to
the S100 family of calcium-binding proteins and plays a role in a variety of inflammatory …

S100A8 and S100A9 promote endothelial cell activation through the RAGE‑mediated mammalian target of rapamycin complex 2 pathway

X Zhong, F Xie, L Chen, Z Liu… - Molecular Medicine …, 2020 - spandidos-publications.com
S100 calcium binding protein A8 (S100A8) and A9 (S100A9) belong to the S100 family of
calcium‑binding proteins and have important roles in inflammation. They increase …