Absorption enhancement strategies in chitosan-based nanosystems and hydrogels intended for ocular delivery: Latest advances for optimization of drug permeation

I Dmour - Carbohydrate Polymers, 2024 - Elsevier
Ophthalmic diseases can be presented as acute diseases like allergies, ocular infections,
etc., or chronic ones that can be manifested as a result of systemic disorders, like diabetes …

Innovative Polymers in Pharmaceutical Chemistry: Revolutionizing Drug Delivery Systems

SR Dachani, A Vashi, AB Mundada… - Polymer-Plastics …, 2024 - Taylor & Francis
Polymers have become a versatile tool in pharmaceutical chemistry through techniques and
new formulation. This review presents an overview of the general topic of drug delivery …

Efficient drug delivery potential and antimicrobial activity of biocompatible hydrogels of dextrin/Na-alginate/PVA

A Nazir, M Abbas, F Kainat, DN Iqbal, F Aslam… - Heliyon, 2024 - cell.com
Ceftriaxone sodium belongs to the third-generation cephalosporin group and is used
intramuscular and intravenous route as a broad-spectrum antibiotic. This research aims to …

From Preformulative Design to in Vivo Tests: A Complex Path of Requisites and Studies for Nanoparticle Ocular Application. Part 2: In Vitro, Ex Vivo, and In Vivo …

C Cimino, LB Vidal, F Conti, ES López… - Molecular …, 2024 - ACS Publications
The incidence of ocular pathologies is constantly increasing, as is the interest of the
researchers in developing new strategies to ameliorate the treatment of these conditions …

Moxifloxacin-loaded nanoparticles of thiolated xyloglucan for ocular drug delivery: Permeation, mucoadhesion and pharmacokinetic evaluation

MA Sufian, G Abbas, A Rasul, M Irfan… - International Journal of …, 2024 - Elsevier
The current study goal was to improve mucoadhesive potential and ocular pharmacokinetics
of nanoparticles of thiolated xyloglucan (TXGN) containing moxifloxacin (MXF). Thiolation of …

Chitosan-based nanoarchitectures for siRNA delivery in cancer therapy: A review of pre-clinical and clinical importance

X Bian, X Yu, S Lu, L Jia, P Li, J Yin, S Tan - International Journal of …, 2024 - Elsevier
The gene therapy has been developed into a new cancer treatment option. Now that we
know which molecular components contribute to carcinogenesis, we may use gene therapy …

Weaponizing chitosan and its derivatives in the battle against lung cancer

H Amin, IM Ibrahim, EHM Hassanein - International Journal of Biological …, 2024 - Elsevier
Lung cancer (LC) is a crisis of catastrophic proportions. It is a global problem and urgently
requires a solution. The classic chemo drugs are lagging behind as they lack selectivity …

From Preformulative Design to In Vivo Tests: A Complex Path of Requisites and Studies for Nanoparticle Ocular Application. Part 1: Design, Characterization, and …

C Cimino, E Zingale, A Bonaccorso… - Molecular …, 2024 - ACS Publications
Ocular pathologies are widely diffused worldwide, and their effective treatment, combined
with a high patient compliance, is sometimes challenging to achieve due to the barriers of …

Impacts of designed vanillic acid-polymer-magnetic iron oxide nanocomposite on breast cancer cells

F Barahuie, D Dorniani, B Saifullah, P Arulselvan… - Heliyon, 2024 - cell.com
The engineered nano-vehicle was constructed using magnetic iron oxide nanoparticles
(MIONs) and chitosan (CTS) to stabilize anticancer agent vanillic acid (VNA) which was …

Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

NI Namazi, H Alrbyawi, AA Alanezi, AF Almuqati… - Pharmaceutics, 2024 - mdpi.com
The objective of this research was to develop a mucoadhesive delivery system that improves
permeation for the administration of poorly absorbed oral medications. Thiolation of xanthan …