There are well-established links between acute inflammation and successful tissue repair
across evolution. Innate immune reactions contribute significantly to pathogen clearance …

Inflammation In the absence of pathogens occurs in all tissues in response to a wide range
of stimuli that cause tissue stress and injury. Such sterile inflammation (SI) is a key process …

Despite lack of tumor control in many models, spontaneous T cell priming occurs frequently
in response to a growing tumor. However, the innate immune mechanisms that promote …

Infection of cells by microorganisms activates the inflammatory response. The initial sensing
of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll …

Damage‐associated molecular patterns (DAMPs) include endogenous intracellular
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …

For over 50 years immunologists have based their thoughts, experiments, and clinical
treatments on the idea that the immune system functions by making a distinction between …

The innate immune system relies on its capacity to rapidly detect invading pathogenic
microbes as foreign and to eliminate them. The discovery of Toll-like receptors (TLRs) …

Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (eg, glucose)
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …

When a cell dies in vivo, the event does not go unnoticed. The host has evolved
mechanisms to detect the death of cells and rapidly investigate the nature of their demise. If …

Unmethylated CpG motifs are prevalent in bacterial but not vertebrate genomic DNAs.
Oligodeoxynucleotides (ODN) containing CpG motifs activate host defense mechanisms …