As depression is projected to become the leading mental disease burden globally by 2030,
understanding the underlying pathology, as well as screening potential anti-depressants …

Depression is the most prevalent and devastating neuropsychiatric disorder. There are
several conventional antidepressants used for the treatment of depression. But due to their …

Plants from the Sceletium genus (Aizoaceae) have been traditionally used for millennia by
the Khoe and Khoen people in southern Africa, as an appetite suppressant as well as a …

Ethnophamacological relevance Morinda officinalis oligosaccharides (MOs) is a mixture of
oligosaccharides extracted from the roots of Morinda officinalis (MO). It is approved by …

Ethnopharmacology relevance Sceletium tortuosum (L.) NE Br.(ST) is an alkaloid-rich
succulent plant with various mechanisms of action that infer psychotropic effects. These …

The intranasal route of drug administration offers an opportunity to bypass the blood–brain
barrier and deliver compounds directly into the brain. Scientific evidence exists for medicinal …

The Flinders sensitive line (FSL) rat is an accepted rodent model for depression that
presents with strong face, construct, and predictive validity, thereby making it suitable to …

Ethnopharmacological relevance Sceletium tortuosum (L.) NE Br., the most sought after and
widely researched species in the genus Sceletium is a succulent forb endemic to South …

Plants from the Sceletium genus (Aizoaceae) have been traditionally used by the Khoe-Sān
people in southern Africa, mainly for thirst and hunger relief, pain reduction and spiritual …

Medicinal plants continue to be a rich source of biomolecules with therapeutic values​​ for
the treatment of anxiety and depression, thus, the study seeks to categorize the species …