[HTML][HTML] Recent advances in degradable synthetic polymers for biomedical applications‐Beyond polyesters

M Dirauf, I Muljajew, C Weber, US Schubert - Progress in Polymer Science, 2022 - Elsevier
Polyesters have been studied intensely over the last few decades and proved to be suitable
for a wide range of applications. Despite all benefits, drawbacks such as eg the acidification …

Surface engineering of cardiovascular devices for improved hemocompatibility and rapid endothelialization

J Zhao, Y Feng - Advanced Healthcare Materials, 2020 - Wiley Online Library
Cardiovascular devices have been widely applied in the clinical treatment of cardiovascular
diseases. However, poor hemocompatibility and slow endothelialization on their surface still …

Local delivery of dual microRNAs in trilayered electrospun grafts for vascular regeneration

M Wen, D Zhi, L Wang, C Cui, Z Huang… - … applied materials & …, 2020 - ACS Publications
Globally growing problems related to cardiovascular diseases lead to a considerable need
for synthetic vascular grafts. For small-caliber vascular prosthesis, it remains essential to …

Polymeric siRNA gene delivery–transfection efficiency versus cytotoxicity

A Kargaard, JPG Sluijter, B Klumperman - Journal of controlled release, 2019 - Elsevier
Within the field of gene therapy, there is a considerable need for the development of non-
viral vectors that are able to compete with the efficiency obtained by viral vectors, while …

Optimization of Mixed Micelles Based on Oppositely Charged Block Copolymers by Machine Learning for Application in Gene Delivery

K Leer, LS Reichel, J Kimmig, F Richter, S Hoeppener… - Small, 2024 - Wiley Online Library
The COVID‐19 mRNA vaccines represent a milestone in developing non‐viral gene
carriers, and their success highlights the crucial need for continued research in this field to …

A summary on non-viral systems for gene delivery based on natural and synthetic polymers

R Sarvari, M Nouri, S Agbolaghi… - … Journal of Polymeric …, 2022 - Taylor & Francis
Gene delivery systems necessitate the gene therapy, which is a unique approach for
applying the tunable genes to treat any diseases. To tackle down the disadvantages of viral …

Matrix-metalloproteinase-responsive gene delivery surface for enhanced in situ endothelialization

L Bai, J Zhao, M Wang, Y Feng… - ACS Applied Materials & …, 2020 - ACS Publications
Although blood-contacting medical devices have been widely used in the biomedical field,
their low endothelialization seriously limits their treatment success. Gene transfection can …

Multifunctional gene carriers with enhanced specific penetration and nucleus accumulation to promote neovascularization of HUVECs in vivo

X Hao, Q Li, J Guo, X Ren, Y Feng, C Shi… - ACS applied materials …, 2017 - ACS Publications
Recently, gene therapy has attracted much attention, especially for the treatment of vascular
disease. However, it is still challenging to develop the gene carriers with high …

Electrospun membranes of PELCL/PCL-REDV loading with miRNA-126 for enhancement of vascular endothelial cell adhesion and proliferation

F Zhou, M Wen, P Zhou, Y Zhao, X Jia, Y Fan… - Materials Science and …, 2018 - Elsevier
Surface modification for rapid endothelialization of vascular biomaterials is known as an
important way to prevent thrombosis and intimal hyperplasia. Moreover, therapeutical …

Ligand targeting and peptide functionalized polymers as non-viral carriers for gene therapy

K Muhammad, J Zhao, I Ullah, J Guo, X Ren… - Biomaterials …, 2020 - pubs.rsc.org
Polymeric gene carriers have been developed to deliver therapeutic genes for treating
various genetic diseases. They may diminish the problems related with viral vectors in terms …