A growing number of diseases seem to be associated with inappropriate deposition of
protein aggregates. Some of these diseases—such as Alzheimer's disease and systemic …

Prion diseases are transmissible, invariably fatal, neurodegenerative diseases which
include Creutzfeldt–Jakob disease (CJD) in humans and bovine spongiform …

Antibodies against the prion protein PrPC can antagonize prion replication and
neuroinvasion, and therefore hold promise as possible therapeutics against prion diseases …

Protein Misfolding Disorders (PMDs) are a group of diseases characterized by the
accumulation of abnormally folded proteins. Despite the wide range of proteins and tissues …

The intracellular expression of the programmed death receptor 1 (PD1) identifies a subset of
naive Treg cells with enhanced suppressive ability; anti‐gen stimulation results in the …

Prions are unconventional infectious agents that cause lethal transmissible
neurodegenerative diseases in human and animals. Prions can be distinguished from other …

The term “prion disease” encompasses a group of neurodegenerative diseases affecting
both humans and animals. Currently, there is no effective therapy and all forms of prion …

Prion diseases are characterized by conversion of the cellular prion protein (PrPC) to a
protease-resistant conformer, the srapie form of PrP (PrPSc). Humoral immune responses to …

Immunotherapy has emerged as a promising therapeutic approach for the treatment of
neurodegenerative disorders, which are characterized by the progressive loss of neurons …

The absence of specific immune response is a hallmark of prion diseases. However, in vitro
and in vivo experiments have provided evidence that an anti-PrP humoral response could …