The ability to fight bacterial infections with antibiotics has been a longstanding cornerstone
of modern medicine. However, wide-spread overuse and misuse of antibiotics has led to …

ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

A global medical crisis is unfolding as antibiotics lose effectiveness against a growing
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …

Over the last 20 years there have been 32 reports of carbapenem-resistant organisms in the
hospital water environment, with half of these occurring since 2010. The majority of these …

Pseudomonas aeruginosa is a ubiquitous organism that is the focus of intense research
because of its prominent role in disease. Due to its relatively large genome and flexible …

Hospital water may serve as a reservoir of healthcare-associated pathogens, and
contaminated water can lead to outbreaks and severe infections. The clinical features of …

The hospital environment is a potential reservoir of bacteria with plasmids conferring
carbapenem resistance. Our Hospital Epidemiology Service routinely performs extensive …

Pseudomonas aeruginosa is an opportunistic bacterial pathogen that is widely occurring in
the environment and is recognized for its capacity to form or join biofilms. The present review …

There have been an increasing number of reports implicating Gammaproteobacteria as
often carrying genes of drug resistance from colonized sink traps to vulnerable hospitalized …

Background Pseudomonas aeruginosa is an opportunistic pathogen with a particular
propensity to cause disease in the immunocompromised. Water systems have been …