Persistent depressive disorder is a chronic mood disorder that is common and often more
disabling than episodic major depression. In DSM-5, the term subsumes several chronic …

PurposePatients with chronic depression (CD) by definition respond less well to standard
forms of psychotherapy and are more likely to be high utilizers of psychiatric resources …

Depression is widely acknowledged to be a heterogeneous entity, and the need to further
characterize the individual patient who has received this diagnosis in order to personalize …

Importance Despite recent increased use of antidepressants in the United States, concerns
persist that many adults with depression do not receive treatment, whereas others receive …

BackgroundThere is growing recognition of the importance of both functioning and quality of
life (QoL) outcomes in the treatment of depressive disorders, but the meta-analytic evidence …

Whereas pharmacological interventions remain the primary treatment for bipolar disorders,
adjunctive psychosocial interventions have the potential to increase adherence to …

Background: Persistent depressive disorder is prevalent, disabling, and often difficult to treat.
The cognitive-behavioral analysis system of psychotherapy (CBASP) is the only …

Problem In several countries, physical activity is now recommended in clinical practice
guidelines as an option for the treatment of subthreshold, mild, and moderate adult …

Recommendations include using large prospective observational studies followed by
pragmatic trials rather than smaller, expensive controlled treatment trials for preliminary …

Background We aimed to synthesize the available evidence on the relative efficacy and
acceptability of specific treatments for persistent depressive disorder. Methods We searched …