Short-read, high-throughput sequencing (HTS) methods have yielded numerous important
insights into microbial ecology and function. Yet, in many instances short-read HTS …

In 2021 the scientific community's efforts have been focused on solving the back-breaking
challenge of the COVID-19 pandemic, but sexually transmitted infections (STI) are still one of …

Syphilis is a globally re-emerging disease, which has marked European history with a
devastating epidemic at the end of the 15 th century. Together with non-venereal treponemal …

The recent development of a system for long-term in vitro culture of the syphilis spirochete,
Treponema pallidum subsp. pallidum, has introduced the possibility of detailed genetic …

Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been
attributed to antigenic variation of its putative outer-membrane protein TprK. In TprK, amino …

Neurosyphilis is caused by Treponema pallidum invading the central nervous system, of
which the incidence is increasing worldwide. Due to its variable clinical manifestations …

Immune evasion and disease progression of Treponema pallidum subsp. pallidum are
associated with sequence diversity in the hypervariable outer membrane protein TprK …

TprK antigenic variation is acknowledged as an important strategy developed by Treponema
pallidum to achieve immune evasion. Previous studies applied short-read sequencing to …

Background The incidence of syphilis continues to increase in the United States, yet little is
known about Treponema pallidum genomic epidemiology within American metropolitan …

The outer membrane proteins (OMPs) of Treponema pallidum subsp. pallidum (T. pallidum),
the etiological agent of the sexually transmitted disease syphilis, have long been a hot …