1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

We present here a review of the photochemical and electrochemical applications of multi-
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …

The four-membered oxetane ring has been increasingly exploited for its contrasting
behaviors: its influence on physicochemical properties as a stable motif in medicinal …

Morpholine is a heterocycle featured in numerous approved and experimental drugs as well
as bioactive molecules. It is often employed in the field of medicinal chemistry for its …

Intramolecular cyclization of nitrogen-containing molecules onto pendant alkenes is an
efficient strategy for the construction of N-heterocycles, which are of paramount importance …

Saturated N-heterocycles are prevalent in biologically active molecules and are increasingly
attractive scaffolds in the development of new pharmaceuticals. Unlike their aromatic …

Morpholine is a frequently used heterocycle in medicinal chemistry and a privileged
structural component of bioactive molecules. This is mainly due to its contribution to a …

Interest in saturated N-heterocycles as scaffolds for the synthesis of bioactive molecules is
increasing. Reliable and predictable synthetic methods for the preparation of these …

Methods that provide rapid access to new heterocyclic structures in biologically relevant
chemical space provide important opportunities in drug discovery. Here, a strategy is …

Piperazine ranks as the third most common N-heterocycle appearing in small-molecule
pharmaceuticals. This review highlights recent advances in methods development for the …