The amyloid hypothesis of Alzheimer's disease has long been the predominant theory,
suggesting that Alzheimer's disease is caused by the accumulation of amyloid beta protein …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

Emerging data suggest that ApoE affects several amyloid β-independent pathways. These
underexplored pathways may provide new insights into Alzheimer's disease pathogenesis …

Liver X receptors (LXRs) are master regulators of cholesterol homeostasis and inflammation
in the central nervous system (CNS). The brain, which contains a disproportionately large …

The prevalence of Alzheimer's disease (AD) continues to rise due to the increasing aging
population. Among the various genetic factors associated with AD, apolipoprotein E (ApoE) …

Recently, large-scale human genetics studies identified a rare coding variant in the ABI3
gene that is associated with an increased risk of Alzheimer's disease (AD). However …

The ubiquitin (Ub)-proteasome system (UPS) is considered as a central protein degradation
system in all eukaryotes. The UPS comprises of several factors such as Ub and Ub-like …

APOE4 is the first identified genetic risk factor and remains as the strongest predictor for late-
onset Alzheimer's disease (AD). Studies of AD patients, AD patient-specific induced …

Alzheimer's disease (AD) is the most common form of dementia, most prevalent in the
elderly population and has a significant impact on individuals and their family as well as the …

Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to
dementia in the elderly population. AD is associated with the buildup of β-amyloid and tau …